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How Does Spironolactone Help Acne

Can You Take Spironolactone While Pregnant

Spironolactone for Acne [Acne Treatment]

Spironolactone is pregnancy category C, which means that risks cannot be ruled out. It should not be taken by women who are pregnant, trying to become pregnant, or are sexually active and not using a reliable form of contraception. Spironolactone should not be taken while pregnant due to potential adverse effects on the developing baby. Based on data from animal studies, oral spironolactone may interfere with the development of primary sex characteristics in male fetuses.

Side Effects And Risks

Aldactone and Lasix can cause similar side effects, but some different ones as well. Below are examples of these side effects.

Mild side effects

These lists contain up to 10 of the most common mild side effects that can occur with each drug, or with both Aldactone and Lasix .

  • Can occur with Aldactone:

* Sex and gender exist on spectrums. Use of the term male in this article refers to sex assigned at birth.

Complications And Side Effects Of Spironolactone For Acne

Most people do not experience noticeable side effects while on spironolactone, but some may experience:

  • Changes in menstrual cycle
  • Frequent urination
  • Headaches
  • Dizziness

Can you drink alcohol while taking spironolactone? It is best to limit alcohol intake while taking spironolactone, as alcohol can increase the side effects, including dizziness.

Spironolactone is a potassium-sparing diuretic. That means even though it flushes out extra water, it wont lower potassium levels.

If youre not avoiding potassium-rich foods , you could enter hyperkalemia, a state of too much potassium.

Hyperkalemia, or too much potassium, can lead to:

  • Abdominal pain

What are the side effects of spironolactone? The most common side effects of spironolactone include:

  • Cramps
  • Breast enlargement
  • Irregular periods

All of these can be triggered by the effects of spironolactone on your hormones. While many women like spironolactone because it may treat acne without birth control, oral contraceptives may help decrease its side effects.

Due to these hormonal side effects, do not take spironolactone if you become pregnant or are sexually active without birth control methods.

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S In Analysis To Handle Protocol Non

All participants will receive the assigned study treatment until unacceptable toxicity, death, loss to follow up, withdrawal of consent or termination of the study by the Sponsor, in accordance with local standards of care. Unacceptable toxicity and death will be considered as failure for the primary criteria analysis. Loss to follow up, missing data for the primary criteria and early termination of the study by the Sponsor will be also considered as failures by the ITTm and not replaced.

Patients who did not fulfil the inclusion criteria after randomization and those who never began their treatment will be replaced. For the clinical secondary criteria analysis, patients with missing data will be withdrawn. Missing data in cost-effectiveness analysis will be handled according to a multiple imputation method in the ITTm sample. If a patient is released from the study preventing the continuation of the study), her data will not be collected, except for safety data .

Procedure For Unblinding If Needed

Can You Use Spironolactone to Treat Acne?

The investigator should inform the Sponsor if unblinding is deemed to be necessary due to an emergency. Unblinding will be performed via the eCRF thanks to a detailed procedure that will be given to each site. Each decoding will be tracked and classified in the investigators management file and in the trial management file.

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How To Use Spironolactone

Spironolactone is taken orally via pill or liquid medication. The most common dosage is between 50mg and 100mg daily, though some individuals may require up to 200mg to see changes in their skin. While it can be taken on an empty stomach, taking it with food can help prevent an upset stomach. Additionally, it is recommended that you take it earlier in the day to avoid having to get up during the night to pee.

So Which Form Is More Effective

Depending on the dose, oral spironolactone is typically more effective than topical spironolactone. In sum:

  • Topical spironolactone works best when paired with other treatments. It can add a powerful punch to other acne-fighting formulas, but it might not be as effective by itself. Its also better suited for individuals who arent a good candidate for oral spironolactone and those who want to avoid the potential risks of oral spironolactone.

  • Oral spironolactone is more effective since it reduces acne-causing sebum production from within your skin. You can also increase the dose to the amount needed for maximal results.

Rather than view one form of spironolactone as more effective than the other or as a replacement, they should be thought of as complements. For best results, if possible, you should use both oral and topical forms of spironolactone. While oral spironolactone is working from the inside out, topical spironolactone is working hard at the skin level to make sure new breakouts are kept in check.

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Spironolactone Might Not Work For You

If you’ve been taking the pill for over three months and your hormonal acne situation isn’t any better, it might be time to try a new dose or another treatment option. “When using it to treat acne, spironolactone is only used in women and tends to work best for women with hormonal acne, menstrual flares, adult-onset acne, or conditions with hormone abnormalities and acne ,” explains Dr. Sejal Shah, cosmetic dermatologist and founder of Smarter Skin Dermatology in New York City “It is also often used in women whose acne is resistant to conventional therapies.”

“At a high enough dose, it has some effect on all women,” adds Dr. Zeichner. “The issue is that at higher doses it may be associated with side effects like breast tenderness or irregular periods, which get in the way with using it.”

Spironolactone Can Banish Hormonal Acne In Just A Few Weekshere’s How It Works

Treat Hormonal Acne with Spironolactone: A Dermatologist Explains | DERM CHAT

Karen Kagha, MD, FAAD, is a Boston-based board-certified dermatologist. She is currently a Cosmetic and Laser Fellow at Harvard Massachusetts General Hospital.

/ Design by Tiana Crispino

In This Article

While hormonal acne is often thought to be just for teens, it’s perfectly normal to experience hormonal acne as an adult. Whether youve tried tweaking your diet or have seen a dermatologist about prescription acne medications like tretinoin, sometimes these small adjustments just aren’t enough to clear tough breakouts.

Typically, when topical ingredients aren’t cutting it, your dermatologist might recommend a medication called Spironolactonean oral blood pressure medication that can be prescribed off-label to treat hormonal acne. And when used as directed, it’s actually quite effective .

So who is a candidate for using Spironolactone for acne, and how does it work? Ahead, dermatologists share everything you need to know.

Meet the Expert

  • Nick Lowe, MD, is a consultant dermatologist and clinical professor, based between the U.S. and England.
  • Susan Raffy is a California-based cosmetic chemist and the president of Susan Raffy Consulting.
  • Justine Kluk, MD, is a dermatologist and acne specialist.
  • David Colbert, MD, is a dermatologist and the founder of the New York Dermatology Group.


Type of ingredient: Oral Medication

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When May A Dermatologist Recommend Spironolactone

Your Dermatologist may recommend Spironolactone if

  • You are female
  • You have hormonal acne or your acne has a significant hormonal component
  • Your acne does not respond well to antibiotics, cream or the oral contraceptive pill
  • You have tried a course of Roaccutane and it either did not work fully or your acne came back quite quickly after completing a course

How To Get Spironolactone

Spironolactone can only be obtained through a prescription from a licensed medical provider .

At Curology we limit our spironolactone prescription strength to 100mg/day. An in-person medical provider may be your best bet for obtaining higher doses of spironolactone. Those taking higher doses of spironolactone may require close monitoring which may include blood tests

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Sequence Generation And Concealment Mechanisms

This balanced block randomization is computer-generated. Subjects are randomized into blocks as the allocation progresses, a block being a subgroup of predetermined size within which there is a random allocation of patients. The software SAS version 9.4 is used for randomization. The randomization will be centralized and stratified based on the following four groups of based on the type of contraception used by the participants:

  • 1.

    Strata 1: implant, generation I and II OCs, progesterone intrauterine device or other kind of hormonal contraception

  • 2.
  • Strata 4: no contraception

  • Spironolactone For Cystic Acne: The Result Is Not Instant

    Spironolactone for acne Elimination

    You will start seeing the effect of spironolactone on cystic acne, but the result is not always instant. Yes, the product drastically reduces hormone, but the result will rarely be instant. So, you should bear this in mind.

    Studies show that the product can take up to three months before resolving the acne issue. The three months duration may even be longer if you do not apply the right dosage of the product to the acne.

    It is, however, better to start the dosage in a small quantity and then increase the dosage gradually until you start seeing the desired result on the acne on your skin. Even if the product resolves the acne problem in months, you will still see result gradually over time. you will see a gradual resolution of the acne as time goes on.

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    Composition Of The Coordinating Centre And Trial Steering Committee

    It has been possible to develop the protocol and carry out the trial thanks to an Executive Committee, which includes a Scientific Committee and a Steering Committee. The Scientific Committee was created and coordinated by Prof. B. Dreno. Its membership comprises a biostatistician and methodologist, the study coordinator, the health economist and the project manager of the clinical investigation centre . The Steering Committee is composed of the members of the Scientific Committee with the addition of the data management team, the study nurse who coordinates assistance for patient inclusion in the other centres and the monitoring Clinical Research Assistant . The Sponsor project manager coordinates this committee and drafts the FASCE newsletter, which provides, among other things, the latest news on patient inclusion and amendments to the protocol.

    What Are The Benefits Of Spironolactone

    Spironolactone helps with skin and hair conditions that are caused by androgens including:

    • Hormonal acne for women in their 20s and 30s
    • Acne during the perimenopause
    • Acne caused by HRT or Testosterone as part of HRT
    • Female pattern hair loss

    Spironolactone may be used alone or in combination with other treatments for acne.

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    Are There Dietary Concerns When Taking Spironolactone

    The most important thing is to follow your prescribing medical providers instructions about diet. In general, people taking spironolactone should avoid excess potassium, which can be found in foods like:

    • Coconut water

    Your Curology provider can work with you to figure out which of these medications are the best ones for you.

    What Happens When You Stop Taking Spironolactone

    Spironolactone Treatment of Hormonal Acne, an Overview

    Unlike an antibiotic, spironolactone can be taken for a prolonged period of time if its successful at treating your acne. If you want to stop taking it, consult a doctor so they can help you devise a plan for weaning off. Stopping the medication suddenly may lead to excess fluid retention and increased blood pressure.

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    You May Feel More Tired Than Usual

    When my body was adjusted to spironolactone, I was so exhausted I could have easily fallen asleep standing up while in line at Whole Foods even though I was taking a very small dose of the medicine. Since then, my energy levels are back to what they used to be before taking the pill. “Spironolactone blocks the hormone aldosterone, which can lead to fatigue,” Dr. Shah explains. “In addition, it can lower the blood pressure, and if this drop is sudden, you may feel tired.”

    Natural Alternatives To Spironolactone For Pms

    If the idea of taking spironolactone or the pill to regulate PMS sounds a bit risky to you, read on. Ive got some other options for you to consider instead.

    Many times, you can attribute PMS to excess estrogen circulating in the body. Its essential that if youre experiencing PMS symptoms that you address this problem. Here are some ways you can assist your body in getting rid of excess estrogen.

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    Spironolactone For Acne: What You Need To Know Before Trying It

    • May 11, 2022
    • 3 min read

    Spironolactone can regulate your hormone levels in order to treat hormonal acne, but changing your hormones should not be your first defense against acne.

    So how does Spironolactone work for acne? It suppresses the uptake of the hormones generally associated with acne. But altering your hormone levels can come with various side effects that can easily be avoided by trying a holistic skin care treatment that treats the excess oil production that causes hormonal acne.

    While those experiencing hormonal acne may find some relief from this hormonal treatment or from oral contraceptives, a well-formulated acne-fighting skincare regimen is likely to be more effective without the cost and side effects that can accompany a new prescription.

    Spironolactone For Acne Side Effects

    Can You Use Spironolactone to Treat Acne?

    Potential side effects of spironolactone include:

    • Breast tenderness
    • Fatigue
    • Increased urination

    Dr. Zeichner says many of these side effects are more likely when the medication is given at higher doses. Its worth noting that there is a black box warning on the drug, but it may not be a cause for genuine concern if you are an otherwise healthy female.

    In one study in rats spironolactone caused solid organ tumors, however it has not been shown to be a problem in humans, advises Dr. Zeichner. The amount of the drug given to rats in the study was significantly higher than the one prescribed to women.

    Spironolactone does not typically cause depression or mood changes. If you do notice changes in mood while taking it, let your healthcare provider know. Sometimes, spironolactone is prescribed to promote hair growth in women because its an antiandrogenthat means it blocks the male hormones that may lead to hair loss in women.

    Because the drug decreases fluid retention, you may lose a small amount of weight while taking it. There isnt any evidence that spironolactone works as a weight loss medication, but it may help with premenstrual bloating and is often prescribed to treat symptoms of PMS and premenstrual dysphoric disorder .

    Recommended Reading: How To Reduce Hormonal Acne

    Oral Spironolactone Is Moderately Effective In Treating Acne

    Ten studies performed to date indicate that oral spironolactone is at least moderately effective in treating acne. While the studies used different methods and looked at different numbers of patients, the results of each study show at least moderate improvement in acne in the majority of patients.4-13 It should be noted that although two of the studies included male patients, doctors almost always prescribe spironolactone only to women.

    Expand to read details of studies

    A 1984 study in the British Journal of Dermatology investigated the efficacy of spironolactone in both men and women with severe acne. Although the researchers examined men, doctors almost always prescribe spironolactone only to women. They randomly assigned 36 participants to receive one of five treatments.

    1. 50mg of spironolactone

    4. 200mg of spironolactone

    5. A placebo

    Researchers in a 1986 study in the same journal gave 21 women 200mg of spironolactone daily for three months. The researchers randomly assigned the women to a treatment group or to a placebo group. This study found that the group taking spironolactone experienced a 66% improvement in the number of acne lesions after three months. In contrast, the women in the placebo group did not experience improvement in their acne. Seventy-three percent of the women who did not take a COC also experienced menstrual side effects, but all of the women persisted. Two women dropped out of the study because of nausea.5

    Aldactone For High Blood Pressure

    Aldactone is FDA-approved to treat hypertension in adults. For this purpose, Aldactone should be used with other blood pressure drugs.

    A decrease in blood pressure can help lower the risk of cardiovascular problems, such as heart attack and stroke. In some cases, these problems can be fatal.

    High blood pressure explained

    As blood flows through arteries, it exerts a force on the artery walls. This is called blood pressure. When the force is higher than usual, its considered high blood pressure.

    Many people with high blood pressure dont have any symptoms of the condition. In fact, its possible for you to have high blood pressure for many years before you notice any symptoms, if you ever have symptoms at all.

    Symptoms of high blood pressure can include:

    If high blood pressure isnt treated, it can lead to serious complications, including damage to your arteries and heart. In rare cases, these complications can be fatal. High blood pressure can also lead to decreased blood supply to your brain, which could result in brain damage.

    Effectiveness for high blood pressure

    According to clinical guidelines from the American College of Cardiology and American Heart Association, spironolactone may be used with other medications to help lower blood pressure.

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    What Are The Side Effects Of Oral Spironolactone

    As with all medications, spironolactone can cause side effects, particularly at higher doses. Most people tolerate low doses of spironolactone well, even for long periods of time. Side effects that can occur at dosages higher than 100mg per day include:

    • Menstrual irregularities, such as increased or decreased menstrual bleeding or breakthrough bleeding, which is bleeding that occurs between periods. Adding a COC to the treatment reduces these side effects.
    • Tenderness or enlargement of the breasts in both males and females. Adding a COC to the treatment can reduce this side effect.
    • Orthostatic hypotension, which is a sudden drop in blood pressure when standing up that can result in dizziness or fainting.
    • Reduced libido .
    • Excessively high potassium level in the blood. This is a dangerous side effect that can cause life-threatening heart problems. However, it is not common in healthy young people. Because of this side effect, people with kidney problems should not use spironolactone. In addition, spironolactone cannot be used with certain medications, including diuretics and ACE inhibitors, which often are used for high blood pressure.3

    Side effects that do not seem to be related to dose include:

    • Tiredness

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